Stem cell therapy

What is stem cell ?

Chronic headache and regenerative medicine

While pain that suddenly becomes painful and subsides in a short period of time is called acute pain, and pain that occurs over a long period of time is called chronic pain.
Chronic pain is caused by long-lasting changes due to diseases such as cancer, rheumatoid arthritis, and herniated discs, and damage to the nervous system. This often causes persistent pain even without noxious stimuli or acute pain associated with trauma.

The categories of chronic pain are as follows, and mainly target the diseases 1~4 below.

1. Nociceptive pain, where noxious stimuli continue to be applied for a long period of time.
2. Neuropathic pain lasting long after initial neuropathies disappear
3. Mixed chronic pain with a mixture of nociceptive and neuropathic pain
4. Spontaneous chronic pain in which there is a tissue lesion causing pain
5. Psychogenic pain

Regenerative treatment for chronic headache is a treatment method to improve pain by the autologous stem cells that the damaged nerve cells collected from the fat of their own and, repair damaged tissue, utilizing that it has the function of secreting anti-inflammatory factor that suppresses inflammation that causes pain.

Maxillofacial area headache

Orofacial pain mainly refers to pain in the trigeminal nerve area, and there are various conditions.
Persistent headaches, headaches where drugs do not work, facial neuralgia,tongue pain, etc.
Trigeminal neuralgia is a recurrent, unilateral short-term blitz that causes sudden onset of pain.
Confined to the area of control of the trigeminal branch, usually triggered by slight cues such as face washing, shaving, smoking, talking, or brushing teeth, however may occur spontaneously.
Targeting autologous stem cell therapy for chronic trigeminal pain.

Wrinkles ・ sagging

The firmness of the skin is maintained by collagen fibers of the dermis layer under the epidermis, and elasticity is maintained by elastic fiber. Collagen fibers, which occupy most of the dermal layer, become thick and dense in the lower layer. On the other hand, because the epidermis is thin and has no elasticity, when tissues such as collagen fibers of the dermis are deformed, the epidermis also becomes uneven. This becomes a wrinkle.

Sagging is a phenomenon in which collagen fibers that keep the skin firm are destroyed by damage such as ultraviolet rays, and it becomes difficult for new collagen fibers to be made with age. Compared to when you were younger, your ability to produce skin cells accurately declined. As a result, the skin itself becomes fragile, and the skin cannot support tissues such as fat and loses gravity and sags.

Wrinkles and sagging are caused by damage caused by dryness, aging, and ultraviolet rays, and a major cause is cell damage due to active oxygen due to lipid peroxide generated by stress etc.

There are three major causes of “sagging”

1. Reduced skin elasticity
2. Decreased metabolic function
3. Muscle weakness
   When elastin which is the main component of collagen and elastic fibers that support the skin’s elasticity decreases, loses elasticity.
   When metabolic function declines, subcutaneous fat becomes thicker and easily falls due to the influence of gravity.
   Also, when facial muscle strength weakens, it becomes impossible to support the skin and subcutaneous fat.

Treatment of “wrinkles” and “sagging” in our clinic

Improvement by MESONA-J

MESONA-J can safely and securely introduce effective ingredients according to skin symptoms such as spots, wrinkles, acne, melasma, whitening, reddish face, tension, moisturizing, and improving skin quality, without pain and without damaging the skin.

Improvement by stem cell therapy

This treatment method injects subcutaneously or intradermally on the face the patient’s own stem cells after culturing the required number of fat-derived stem cells extracted from the patient’s own abdominal and let fat to improve facial aging symptoms such as wrinkles and sagging.
This is a skin regenerative medicine in which aged cells slowly cleanse the skin by the action of injected stem cells.

Stem cell therapy is a fundamental treatment that can restore skin function weakened by aging, etc. and decrease of collagen fibers and decreased skin cell function that cause aging such as wrinkles and sagging, by transplanting stem cells cultured and expanded with high regenerative capacity. For that reason, stem cells injected into the skin change over time to cells that aim to improve the skin condition and wrinkles, gradually recover their function, and improve wrinkles and sagging.
Also, if you re-inject regularly, you can feel a better effect.

Atopic dermatitis

Atopic dermatitis is a disease associated with skin inflammation that is often seen in people who are already prone to allergies, who have sensitive skin characteristics, and who have a weak skin barrier function. It is thought that various environmental factors such as invasion of allergens (tick, dust, food, etc) and stress overlap. The main symptoms are “eczema” and “itch”, which improve and worse repeatedly and this disease does not heal easily.

Atopic dermatitis is an inflammatory disease, as indicated by the word “flame”, that occurs mainly in the skin.
Many patients with allergic disease have reduced mucosal immunity. The causes are found to be a decrease in intestinal immunity, deterioration of intestinal environment, deficiency of nutrients that control mucosal immunity, accumulation of heavy metals, and impaired excretion.

At our clinic, in addition to checking and supplementing nutrients that control mucosal immunity such as vitamins and minerals by detailed blood test, performing treatments that combine improvement of intestinal environment, drip therapy, dietary guidance, as oral condition reflects general condition, oral environment improvement, etc.

Also, taking advantage of the function of autologous fat-derived stem cells to secrete immunosuppressive factors and anti-inflammatory factors, we are implementing therapeutic methods to improve disease.
This treatment is intended for patients with atopic dermatitis, collecting and culturing only stem cells extracted from the patient’s own fat, and returning the stem cells to the body by IV infusion.

Treatment flow

1. Reservation

   Our clinic must be fully booked. Please call 03-5542-1177 and make a reservation from counselling reservation form.

2. Interview (Counselling)・Preoperative blood sampling

   Doctors listen to the patient’s symptoms, purpose, and hopes and explain the characteristics, expected effects, and risks of stem cell regenerative therapy
   Develop the optimal treatment plan (Number of doses, method, times) for the patient’s condition
   Have a blood test, tumor market, and allergy test before surgery
   Please bring if you have inspection data from another hospital

3. Fat collection

   Make an incision of about 5mm on the skin in the navel and collect about 10mg (1~2 rice grain) of fat and blood necessary for culture.
   Almost no postoperative pain and no visible scratches
   Please refrain from bathing and excessive exercise on the day

4. Culture

   Immediately after collection, fat tissue is transported to a contracted partner culture facility under strict temperature control.
   After arrival, immediately a dedicated incubator cultivates the fat-derived stem cells for about 3~4 weeks in a sterile cell culture processing room and grows to the number of cells required for treatment.
   Work closely with affiliated facilities and receive reports on culture status one after another.
   There are individual differences in the time required to culture up to the number of stem cells required for treatment
   If abnormalities are observed in the culture process, fat collection or culture may be stopped

5. Note

   About 2 weeks after the start of culture, the final culture completion time will be determined.
   At this point, discuss and determine treatment (administration) date with patient
   *As a general rule, in order to enhance the therapeutic effect and reduce the risk, the determined administration date cannot be changed.

6. Administration (Treatment)

   For local injection therapy or drip therapy, give stem cell administration.
   If the next administration is scheduled, collect the blood necessary for the next culture
   Local injection may cause some swelling and internal bleeding after surgery.

7. Post-operative monitoring

   Visit our clinic one week after treatment to check for symptoms.
   After that, one month later, three months later, visit our clinic for follow-up observation.

8. Preparation for next administration

   Preparation for next administration
   If multiple doses are to be administered, start expansion of stem cells that had been cryopreserved in the facility on primary culture at the time of initial collection.